Increased levels of Lp(a) are related with family risk factors of CVD in children and adolescents from Maracaibo (Venezuela)
Year: 2007
Type: article
Study design: Observational Study
Abstract: "Objective: The aim of the study was to determine Lipoprotein (a) (Lp(a)) concentrations in a sample of subjects from Maracaibo (Venezuela) and to find out the relationship of family risk factors for cardiovascular disease and their Lipoprotein(a) levels. Methods: 227 healthy individuals between 5 and 19 years f age, of both genders and multi-ethnic origins were selected. A complete background clinical chart and laboratory test was made for each patient in order to discard cardiovascular diseases and confirm their healthy state. The Lp (a) concentration was determined using the double antibody ELISA method. For inferential statistical analysis one factor ANOVA tests and "t" student test for independent observations were used according to each case, considered significant when p value was <0.05. Results: No significant differences were observed when evaluating Lipoprotein (a) levels according to sex in all ages. Males showed no significant difference in Lipoprotein (a) levels between groups but, in females a significant lower level (p<0.03) in the group of 5-9 years was found. When considering only age, significant lower levels were observed (p<0.03) in the 5-9 years old group. When studying family risk factors of cardiovascular diseases, it was found that group with family risk factors had a significantly higher Lipoprotein(a) concentration (p<0.01) than those without family¿s risk factors, observing that those who had 4 or more factors exhibited a significant higher concentration, than those with 2-3 risk factors (30.6±4.5 mg/dl vs 18.5±12.2 mg/dl, p<0.009) and than those with 1 risk factor (30.6±4.5 mg/dl vs 21.6±1.4 mg/dl, p<0,03) Conclusion: These results emphasize the clusters of family's risk factors of cardiovascular disease with higher Lp(a) levels and also indicate that the evaluation of its concentration should be taken as an independent risk factor of atherosclerosis for the population in developmental ages."
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1490417304