Work

Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies.

Year: 2014

Type: review

Abstract: Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warburg's discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.

Source: PubMed Central

DOI: 10.7497/j.issn.2095-3941.2014.01.001

Authors: Liem Minh Phan, Sai-Ching Jim Yeung, Mong-Hong Lee

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green