Work

Cardioprotection by Volatile Anesthetics: From Bench to Bedside and Back

Year: 2011

Type: article

Abstract: Ischemia and reperfusion (I/R) injury of the heart can be ameliorated by volatile anesthetics (VAs). Application of VAs prior to the ischemic event triggers endogenous cardioprotective program that persists even after anesthetic removal, and it is called anesthetic-induced preconditioning (APC) (1). VAs can also reduce infarct size if applied during the reperfusion period (anesthetic postconditioning), where they can also exert protection by the direct effects on cardiac cells, specifically on the mitochondrial function. In this review, authors will summarize the fundamental concepts related to cardioprotection by VAs and implementation of research based on animal models to clinical practice. We will specifically address the role of human stem cell-based models in studying normal cardioprotective pathways, and more importantly, in studying certain diseases, such as diabetes mellitus that negatively affect APC.

Source: University of Zagreb University Computing Centre (SRCE)

Authors: Filip Sedlić, Ana Šepac, Maria Muravyeva, Zeljko J. Bosnjak

Institution: Medical College of Wisconsin

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: MECHANISMS OF ANESTHETIC CARDIOPROTECTION, Anesthetics and Cardiac Signal Transduction