Year: 2013
Type: preprint
Abstract: This note investigates a number of scenarios in which unadjusted testing following a blinded sample size re-estimation leads to type I error violations. For superiority testing, this occurs in certain small-sample borderline cases. We discuss a number of alternative approaches that keep the type I error rate. The paper also gives a reason why the type I error inflation in the superiority context might have been missed in previous publications and investigates why it is more marked in case of non-inferiority testing.
Source: arXiv (Cornell University)
Authors: Glimm, Ekkehard, Läuter, Jürgen
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W1491332324