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Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics

Year: 2015
Type: review
Abstract: It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor.
DOI: 10.1155/2015/296167
Institution: Mayo Clinic
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,830
Funders: Mayo Clinic, Paradifference foundation, National Institutes of Health, Center for Individualized Medicine, Mayo Clinic, National Cancer Institute, National Institute of General Medical Sciences
Awards: G2484122572, Understanding the epigenetic basis of human familial paraganglioma, G4996953109, G5995948298, The Mayo Clinic IMSD: Developing scientists through disease-relevant research, Molecular Basis of Familial Paraganglioma, Medical Scientist Training Program at Mayo Clinic
OpenAlex ID: W1492601114
FWCI: 0.318
Cites: 144
Cited by: 52
Related to: 10