Work

Embryonic stem cells as sources of donor-independent platelets

Year: 2015

Type: article

Abstract: The creation of a donor-independent source of platelets has been challenging; however, recent advances show growing promise for alternative platelet sources. Pluripotent stem cells have the capacity to differentiate into mature megakaryocytes with the ability to produce functional platelets. In this issue of JCI, Noh et al. provide a proof-of-principle demonstration that embryonic stem cells can be used to produce platelets on a clinical scale by controlling the level of the transcription factor GATA1. This study emphasizes the importance of precise regulation of gene expression for regenerative medicine applications.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci82348

Authors: Matthew C. Canver, Daniel E. Bauer, Stuart H. Orkin

Institutions: Harvard University, Boston Children's Hospital, Dana-Farber Cancer Institute, Howard Hughes Medical Institute

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Howard Hughes Medical Institute