Identification of new epilepsy treatments: Issues in preclinical methodology
Year: 2012
Type: review
Abstract: Preclinical research has facilitated the discovery of valuable drugs for the symptomatic treatment of epilepsy. Yet, despite these therapies, seizures are not adequately controlled in a third of all affected individuals, and comorbidities still impose a major burden on quality of life. The introduction of multiple new therapies into clinical use over the past two decades has done little to change this. There is an urgent demand to address the unmet clinical needs for: (1) new symptomatic antiseizure treatments for drug-resistant seizures with improved efficacy/tolerability profiles, (2) disease-modifying treatments that prevent or ameliorate the process of epileptogenesis, and (3) treatments for the common comorbidities that contribute to disability in people with epilepsy. New therapies also need to address the special needs of certain subpopulations, that is, age- or gender-specific treatments. Preclinical development in these treatment areas is complex due to heterogeneity in presentation and etiology, and may need to be formulated with a specific seizure, epilepsy syndrome, or comorbidity in mind. The aim of this report is to provide a framework that will help define future guidelines that improve and standardize the design, reporting, and validation of data across preclinical antiepilepsy therapy development studies targeting drug-resistant seizures, epileptogenesis, and comorbidities.
Source: Epilepsia
Institutions: Albert Einstein College of Medicine, Stanford University, Harvard University, Massachusetts General Hospital, University of Pavia, University of California, Los Angeles, University of Veterinary Medicine Hannover, Foundation, Baylor College of Medicine, University of Eastern Finland, Kuopio University Hospital, National Institutes of Health, National Institute of Neurological Disorders and Stroke, University of Utah, The Royal Melbourne Hospital, The University of Melbourne, University of Ferrara
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1043089433, Clinical Research Program for the Partial Epilepsies, G1354534450, G1701614771, Consequences of Prolonged Febrile Seizures in Childhood, G2034588916, G2142641812, Early Randomized Surgical Epilepsy Trial, IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS, Impact of Initial Therapy and Response on Long Term Outcome in Children with CAE, G379978089, Age Related Seizure Suppression, In Vivo Studies of the Epileptic Hippocampus, Epilepsy and dendritic excitability, Cincinnati Neuroscience Clinical Trials Research Center (CinciNEXT), The role of brainstem in the generation of infantile spasms, Interneuron based mechanisms of temporal lobe epilepsy, Ictogenesis in a model of temporal lobe epilepsy, G8357409345, G8935688307, Excitability and Plasticity of Developing Epileptic Brain
OpenAlex ID: W1492931325