Year: 2013
Type: article
Abstract: Conventional vaccines are based on the application of diverse biochemical, microbiological andimmunological methods over causal agents of diseases. Despite of success reached in vaccines for controlling andpreventing a lot of infectious pathologies, in some other instances the results have not been rather fruitful, so thatexploring new approaches and possibilities is imposed. The development and increase of the molecular biologymeans a revolution for designing new vaccines against a great variety of pathogenic microorganisms causing diseasesthat affect mankind and animals. From knowledge on whole genome sequences of these microorganisms incombination with new advanced technologies such as bioinformatics, DNA microarrays and proteomics it has beenpossible to identify new important antigens for the development of new vaccine candidates. The combinationgenomics – proteomics has rendered great advances in discovering “target” sites of vaccines against pathogenicbacteria. The ideal vaccine must be pathogen – specific, harboring conserved antigens in each strain, therefore havinga universal cover, with the minimal number of antigens. Based on that knowledge, all antigens in silico may bepredicted a priori, without growing the microorganism in vitro. This new approach has been successfully applied toidentifying new antigens in Bordetella pertussis as well, which may be evaluated further for vaccine purposes,therefore representing a serious global effort, just to face whooping-cough or pertussis reemergence
Language: Spanish
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1493834986