Year: 2014
Type: editorial
Abstract: essential for the maintenance of genome integrity and cells to survive DNA interstrand crosslink (ICL) by coordinating DNA damage repair through translesion DNA synthesis (TLS), nucleotide excision repair (NER) and homologous recombination (HR). Besides ICL, the FA signaling pathway is activated by different kinds of genotoxins and plays an important role in the activation of the ATM DNA damage and ATR intra-S phase checkpoints. There are fifteen FANC genes identified in FA or FA-like patients. FA-pathway deficient cells display spontaneous DNA strand breaks under normal growth conditions and defect of DNA damage checkpoint activation in response to DNA damage or replication stress [1]. FANCD2 is the critical component of FA signaling. In response to ICL, the FA pathway activates
Source: Oncotarget
Authors: Changxian Shen, Peter J. Houghton
Institution: Nationwide Children's Hospital
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1494237671