Efeitos de bifosfonatos e estatinas na reparação de fraturas em tíbias de ratas com osteoporose induzida com dexametasona
Year: 2008
Type: article
Abstract: Osteoporosis is a disease characterized by a decrease in bone mass and a consequent increase in the incidence of fractures, which demands preventive methods and effective treatment of the fractures. Some studies demonstrate that not only the osteoporosis, but drugs such as alendronate, promote the non-consolidation of fractures, presumably because of the imbalance in the osteoblast and osteoclast activities caused by this drug. This article describes a comparative study of the effects of alendronate sodium, risedronate sodium, atorvastatin calcium and lovastatin on the repair of fractures in dexamethasone-induced osteoporotic female rats. The effects of those drugs were analyzed by means of the biochemical markers calcium, phosphorus, albumin, total proteins and alkaline phosphatase and a histomorphometric examination of the trabecular bone density. Other morphometric data used were the length, thickness, bone callus diameter and density of the shinbones. The biochemical results showed no significant differences. Through the morphometry and histomorphometry it was possible to verify the induction of osteoporosis by the glucocorticoid, as well as the improvements in bone density, trabecular bone density and diameter of the bone callus, in all treated groups. These techniques showed that the bone recovery was comparable to the normal group, demonstrating that the drugs used are effective in osteoporotic animals subjected to fracture. However, the best effects were obtained with alendronate
Institution: Universidade Federal de Viçosa
Language: Portuguese
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1494363080