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Mass Production and Size Control of Lipid–Polymer Hybrid Nanoparticles through Controlled Microvortices

Year: 2012
Type: article
Abstract: Lipid-polymer hybrid (LPH) nanoparticles can deliver a wide range of therapeutic compounds in a controlled manner. LPH nanoparticle syntheses using microfluidics improve the mixing process but are restricted by a low throughput. In this study, we present a pattern-tunable microvortex platform that allows mass production and size control of LPH nanoparticles with superior reproducibility and homogeneity. We demonstrate that by varying flow rates (i.e., Reynolds number (30-150)) we can control the nanoparticle size (30-170 nm) with high productivity (∼3 g/hour) and low polydispersity (∼0.1). Our approach may contribute to efficient development and optimization of a wide range of multicomponent nanoparticles for medical imaging and drug delivery.
Source: Nano Letters
DOI: 10.1021/nl301253v
Authors: YongTae Kim, Bomy Lee Chung, Mingming Ma, Willem J. M. Mulder, Zahi A. Fayad, Omid C. Farokhzad, Robert Langer
Institutions: Koch Institute for Integrative Cancer Research At MIT, Brigham and Women's Hospital, Harvard University, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Icahn School of Medicine at Mount Sinai
Language: English
Open Access status: green
OpenAlex ID: W1494925806
FWCI: 7.467
Cites: 30
Cited by: 234
Related to: 10