Work

Role of T Follicular Helper cells in Multiple Sclerosis.

Year: 2015

Type: article

Abstract: Multiple Sclerosis (MS) is a chronic, inflammatory and neurodegenerative disease which results from the destruction of myelin and associated collateral tissue damage within the central nervous system (CNS). MS is a highly diverse disease with different clinical profiles. During the past decade, several new treatment options have been introduced, but no treatment completely stops the disease progression. Therefore deeper understanding of the disease mechanism is necessary to develop novel therapeutic strategies. While yet to be proven, there is evidence suggesting the involvement of T follicular helper (Tfh) cells, a CD4 T cell subset specialized for the provision of help to B cells, in the pathogenesis of MS. In this review, I will discuss the potential pathogenic roles of Tfh cells in the course of MS.

Source: PubMed

Author: Nathalie Schmitt

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Award: Novel Innate and Adaptive Immunity Pathways Lead to Human Systemic Autoimmunity

OpenAlex ID: W1495012795

FWCI: 2.143

Cites: 51

Cited by: 27

Related to: 10