Work

Localization and characterization of vasopressin-binding sites in the amygdala of the rat brain

Year: 1984

Type: article

Abstract: Putative receptors for arginine-vasopressin (AVP) in rat brain were localized and characterized using autoradiographic and radioligand-binding techniques. When brain slices were incubated with tritium-labeled vasopressin, an intense concentration of binding sites was identified which included the medial aspects of the amygdala. Binding of labeled AVP to membrane preparations from this brain region was saturable, specific, reversible, and of high affinity. An antagonist of the peripheral pressor activity of vasopressin was found to be a potent competitor for binding to this site.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.04-07-01764.1984

Authors: DM Dorsa, FM Petracca, DG Baskin, LE Cornett

Institutions: University of Washington, Geriatric Research Education and Clinical Center, United States Department of Veterans Affairs, Veterans Health Administration

Language: English

Topic: Neuroendocrine regulation and behavior

Subfield: Social Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: hybrid