Work

Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt( iv ) prodrugs

Year: 2014

Type: article

Abstract: A series of Pt(IV) prodrugs has been obtained by oxidative halogenation of either cisplatin or carboplatin. Iodobenzene dichloride is a general reagent that cleanly provides prodrugs bearing axial chlorides without the need to prepare intervening Pt(IV) intermediates or handle chlorine gas. Elemental bromine and iodine afford Pt(IV) compounds as well, although in the case of the iodine-mediated oxidation of carboplatin, an amido-bridged Pt(IV) side product also formed. A detailed analysis of the changes in spectroscopic and structural parameters induced by varying the axial halide is presented. A number of recurring motifs are observed in the solid state structures of these compounds.

Source: Dalton Transactions

DOI: 10.1039/c4dt02627f

Authors: Timothy C. Johnstone, Sarah M. Alexander, Justin J. Wilson, Stephen J. Lippard

Institution: Massachusetts Institute of Technology

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Awards: G1349028959, CHEMISTRY AND BIOLOGY OF PLATINUM ANTICANCER DRUGS, Understanding and Improving Platinum Anticancer Drugs, G9000090961