Oxidación E Inflamación En La Hiperlipidemia Familiar Combinada
Year: 2007
Type: dissertation
Study design: Observational Study
Abstract: Familial combined hyperlipidemia (FCH) is a frequent disease with a prevalence of 1-3% in general population, characterized by different familial lipoproteic phenotypes, usually related with changes in exogen factors. Diagnosis is based in familial evaluation and elevated plasmatic apo B. Main pathogenic pathways, although not completely known, are: VLDL overproduction in liver, decreased lipoprotein lipase activity, defect in adipose tissue metabolism and insulin resistance (IR). Nevertheless organic damage, the beginning and appearance of cardiovascular disease is heterogeneous in these patients so other risk factors (not only dyslipidaemia) should exist to explain this variability. Two emergent and non studied factors are oxidative stress (OE) and inflammation. FCH is a genetic model of mixed hyperlipidaemia with insulin resistance, defect in postprandial lipaemia and early atherosclerosis. The hypothesis proposed is: in FCH should exist OE and activation of inflammatory markers implicated in the beginning and progression of atherosclerosis and them should be related to IR degree. Forty-two FCH, non diabetic, non smoker, non hypertensive and non treated subjects in primary prevention consecutively selected and twenty-four controls were studied. Clinical and anthropometric parameters (blood pressure, age, weight, height and body mass index), biochemical parameters (lipid and glucose profile), OE parameters (8-oxo-dG, MDA, GSSG and GSSG/GSH as markers of systemic oxidation; SOD, catalase and GPX as antioxidant systems; and GSH as reduction marker) and markers of inflammation (NF-κβ, adiponectine, IL-1, IL-6 and hsCRP) were determined. The analysis of results showed: - FCH is a genetic model of mixed dyslipidaemia with IR. - In FCH subjects oxidative markers are elevated and antioxidant systems are decreased. - Systemic inflammation is elevated in FCH subjects. - NF-κβ as clue regulator of inflammatory and oxidative process is elevated in FCH subjects. - Anthropometric parameters (type and degree of obesity) do not influence oxidation and inflammation in FCH subjects neither control subjects. - IR is independently related to inflammation and oxidation parameters in FCH subjects. - Inflammatory state is a independent predictor factor of IR in FCH subjects without relation to type and degree of obesity and dyslipidaemia.
Author: Sergio Martínez‐Hervás
Language: Spanish
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1495878825