Regulation of the Salmonella typhimurium flavohemoglobin gene. A NEW PATHWAY FOR BACTERIAL GENE EXPRESSION IN RESPONSE TO NITRIC OXIDE. VOLUME 273 (1998) PAGES 34028-34032
Year: 2006
Type: article
Abstract: Regulation of the Salmonella typhimuriumFlavohemoglobin Gene: A NEW PATHWAY FOR BACTERIAL GENE EXPRESSION IN RESPONSE TO NITRIC OXIDEJournal of Biological ChemistryVol. 273Issue 51PreviewFlavohemoglobins, a family of two-domain proteins with homology to vertebrate hemoglobins, are found in a variety of prokaryotic and eukaryotic microorganisms. Recent studies suggest a role for these proteins in nitrogen oxide metabolism. We now show that nitric oxide donors positively regulate a chromosomal flavohemoglobin (hmp)/lacZ operon fusion in Salmonella typhimurium. hmp gene expression in the presence of NO⋅ is independent of the SoxS, OxyR, and FNR transcription factors and instead relies on inactivation of the iron-dependent Fur repressor. Full-Text PDF Open Access Strain MCS38 has been found to have the lacZ integration in the iroC locus instead of the hmp locus and therefore reflects regulation of the iroC gene.
Source: Journal of Biological Chemistry
Authors: Michael J. Crawford, Daniel E. Goldberg
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W1496441353