The Diagnostic Accuracy of Urine Lipoarabinomannan Test for Tuberculosis Screening in a South African Correctional Facility
Year: 2015
Type: article
Study design: Observational Study
Abstract: BACKGROUND: We evaluated the diagnostic accuracy of the urine lipoarabinomannan (LAM) antigen detection assay (Clearview TB-ELISA) to screen for tuberculosis in a South African correctional facility. METHODS: Between September 2009 and October 2010, male offenders were screened for tuberculosis (symptoms, chest radiograph, two spot sputum specimens for microscopy and culture), and urine tested for LAM. Sensitivity, specificity and predictive values of LAM were calculated using definite and probable tuberculosis combined as our gold standard. FINDINGS: 33/871 (3.8%) participants (26% HIV-positive) had tuberculosis. Amongst HIV-positive vs. HIV-negative offenders the sensitivity and specificity of LAM was 7.1% vs. 0% and 98.5% vs. 99.8% respectively. CONCLUSION: Urine LAM ELISA has inadequate sensitivity for TB screening in this population.
Source: PLoS ONE
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Funders: U.S. Department of Health and Human Services, National Institute for Health and Care Research, University of Oxford, Inyuvesi Yakwazulu-Natali, National Health Laboratory Service, Centers for Disease Control and Prevention, Medical Research Council, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
OpenAlex ID: W1496866041