Work

Studies on Encephalitogenic Fragments of Myelin Protein. I. Synthesis of Tryptophan-containing Fragments

Year: 1973

Type: article

Abstract: Four peptides, H-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH, H-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH, H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH and H-Arg-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH were synthesized by the classical method and tested for the induction of experimental allergic encephalomyelitis in guinea pigs. Consequently, it was found that the length limit of the peptide chain for the induction of the disease was the nonapeptide, H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.21.2627

Authors: KENJI SUZUKI, TAKASHI ABIKO, NOBUYOSHI ENDO, YUSUKE SASAKI, JIRO ARISUE

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1496996111

FWCI: 1.53

Cites:

Cited by: 7

Related to: 10