Retinoic acid induces transglutaminase activity but inhibits cornification of cultured epidermal cells.
Year: 1982
Type: article
Abstract: In cultured mouse epidermal basal cells, retinoic acid is a potent inducer of transglutaminase, the enzyme responsible for isodipeptide bond formation in protein cross-linking in the production of the cornified membrane during terminal differentiation. Paradoxically retinoic acid also inhibits the formation of the cross-linked envelope and greatly reduces the level of dipeptide bond formation in epidermal cells induced to differentiate by calcium. These results suggest a novel mechanism by which retinoids can modify transglutaminase activity and epidermal differentiation.
Source: Journal of Biological Chemistry
Authors: S H Yuspa, T Ben, P Steinert
Institution: National Institutes of Health
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W1497338732