Year: 2004
Type: dissertation
Study design: Observational Study
Abstract: The purpose of this thesis is to investigate the impact of the ACE (I/D) polymorphism on systemic and renal hemodynamics in diabetes, by physiological studies exploring its impact on RAAS function, in conditions with different background RAAS activity. The general hypotheses underlying our studies are, first, that ACE (I/D) polymorphism exerts its effects by modulating RAAS function, and second, that these effects are modulated by differences in background RAAS activity, induced by environmental factors. We studied uncomplicated type 1 diabetic patients to provide a well defined, homogenous population. Furthermore, by studying this specific population, the information obtained on early abnormalities in the RAAS might offer clues for prevention of diabetic complications in the future.
Author: P. T. Luik
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1497413603