Year: 2011
Type: dissertation
Abstract: Mechanical ventilation is a lifesaving treatment in critically ill neonates. However, \nmechanical ventilation is also one of the most important risk factors (Table 1) of Bronchopulmonary \ndysplasia (BPD), the most common chronic lung disease in infancy with \nlong-term pulmonary and neurological complications (1). Exposure of immature lungs \nto positive pressure ventilation results in oxidative stress and ventilator-induced lung \ninjury. The resulting injury and inflammation lead to abnormal developmental and \nreparative processes in the lung. \nThis general introduction outlines the current knowledge regarding Bronchopulmonary \ndysplasia related to lung development, mechanisms of ventilator-induced lung \ninjury, mechanosensing and mechanotransduction and pathways involved in the \npathogenesis of BPD related to mechanical ventilation.
Author: André A. Kroon
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1497881681