Work

Identification of a polypeptide associated with the malignant phenotype in acute leukemia.

Year: 1988

Type: article

Abstract: A novel polypeptide, designated p18, was detected in a variety of hematopoietic cells by two-dimensional polyacrylamide gel electrophoresis. Quantitative analysis of p18 indicated its occurrence in a substantially greater amount in acute leukemia relative to nonleukemic cells. The increased amount of p18 in leukemia could not be explained on the basis of specific lineage, differentiation stage, or cell proliferation and thus appears to be a part of the malignant phenotype of the leukemic cells.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(18)37630-0

Authors: S M Hanash, J R Strahler, R Kuick, E H Chu, D Nichols

Institutions: University of Michigan, Michigan Medicine

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430