Work

The 3D-structure of the Immunoglobulin Heavy Chain Locus: implications for long-range genomic interactions [supplemental data]

Year: 2008

Type: article

Abstract: The immunoglobulin heavy-chain (Igh) locus is organized \ninto distinct regions that contain multiple variable \n(VH), diversity (DH), joining (JH) and constant \n(CH) coding elements. How the Igh locus is structured \nin 3D space is unknown. To probe the topography of \nthe Igh locus, spatial distance distributions were determined \nbetween 12 genomic markers that span the \nentire Igh locus. Comparison of the distance distributions \nto computer simulations of alternative chromatin \narrangements predicted that the Igh locus is \no

Source: RePub (Erasmus University Rotterdam)

Authors: Suchit Jhunjhunwala, Menno C. van Zelm, Mandy Peak, Steve Cutchin, Roy Riblet, Jacques J. M. van Dongen, Frank Grosveld, Tobias Knoch, Cornelis Murre

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Deutsches Krebsforschungszentrum, Koninklijke Nederlandse Akademie van Wetenschappen, Bundesministerium für Bildung und Forschung, National Institutes of Health, University of California, San Diego

Award: Verbundprojekt D-Grid_MediGRID: MediGRID - Ressourcenfusion für Medizin und Lebenswissenschaften, Teilmodul: Fachliche und administrative Projektkoordinierung, Koordinierung Industrieforum

OpenAlex ID: W1499137079

FWCI:

Cites:

Cited by:

Related to: 10