Work

Primary murine Chlamydia trachomatis pneumonia in B-cell-deficient mice

Year: 1987

Type: article

Abstract: Mice were rendered deficient in B-cell activity by treatment with anti-mu antibody from birth. These animals were then infected intranasally with murine Chlamydia trachomatis (murine pneumonitis agent [MoPn]). They produced neither local nor systemic antibody to MoPn but had intact delayed-type hypersensitivity to MoPn. Anti-mu-treated mice were not significantly more susceptible to primary invasive infection with MoPn than were control mice, and unrestricted multiplication with MoPn did not occur. The dominant immune response controlling this type of infection is not likely to be antibody.

Source: Infection and Immunity

DOI: 10.1128/iai.55.10.2387-2390.1987

Authors: D M Williams, B Grubbs, J Schachter

Institution: Audie L. Murphy Memorial VA Hospital

Language: English

Topic: Reproductive tract infections research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases