Osteoporosis y enfermedad cardiovascular
Year: 2007
Type: article
Abstract: Cardiovascular disease (CD) and osteoporosis are frequent diseasesin adult population, whose frequency increases with age. Thus, with the increaseof life expectancy, they become relevant health care issues. Both ECV and osteoporosisdepends on the coexistence of multiple risk factors, and prevention policystresses in controlling those modifiable. ECV and osteoporosis have commonetiological factors involving cholesterol biosynthesis and lipid oxidation, whoseelucidation supports a relevant research topic. Skeletal growth and maintenancedepends on the balance between bone formation and resorption achieved throughthe process of bone modelling and bone remodelling, controlled by bone tissuecells (osteoblasts –OB-, osteoclasts –OC- and osteocytes), the OB are responsiblefor bone formation, OC of bone resorption, while osteocytes are key pieces of thebone mechanic sensorial network. The main links between CVD and osteoporosisare the key role of the mevalonate pathway in cholesterol synthesis and OC activation,and the role of oxidised lipids for atherosclerosis development and theconversion of OB-precursor cells in adipocites, reducing OB formation and favouringosteoporosis. In the light of these issues, cholesterol-lowering and antioxidantsubstances can exert bone protector effects, and the search of drugs effective onboth targets support a current research direction, outstanding in the preventionor treatment of such diseases.
Authors: Sarahí Mendoza, Miriam Noa, Rosa Más
Language: Spanish
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1499486661