Synthetic study of cis-3-amino-4-(1-hydroxyalkyl)azetidin-2-ones using L-aspartic acid as a chiral synthon.
Year: 1986
Type: article
Abstract: The stereoselective synthesis of cis-3-amino-4-(1-hydroxyalkyl)azetidin-2-ones from L-aspartic acid is described. The thermodynamically less stable isomers with 3, 4-cis stereochemistry, key intermediates for the synthesis of various substitutes monobactams, were obtained by hydrogenation of the 3-oxyimino-azetidin-2-ones prepared from azetidin-2-ones and isoamyl nitrite. Furthermore, some simple analogues of monobactams were synthesized.
DOI: 10.1248/cpb.34.2732
Authors: YOSHIO TAKAHASHI, HARUO YAMASHITA, SUSUMU KOBAYASHI, MASAJI OHNO
Institution: The University of Tokyo
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W1500090038