The correlation between gatifloxacin’s acute adverse reaction and intravenous drip velocity
Year: 2013
Type: article
Abstract: OBJECTIVE: To investigate the correlation between acute adverse reaction (AAR) and intravenous drip velocity of gatifloxacin. METHODS: Patients who had received intravenous gatifloxacin (0.2g/100 ml) infusion in the Emergency Center, Zhongnan Hospital, Wuhan University, Wuhan, China from January to August 2012 were enrolled in this study. Patients were randomly divided into 3 groups according to different drip velocities: Group A: velocity ≤10 drops per minute; Group B: <10 velocity ≤20 drops per minute; Group C: <20 velocity ≤30 drops per minute. The AAR and demographic data of patients were documented. RESULTS: Acute adverse reaction of the skin and digestive system were significantly positively related to intravenous drip velocity. The AAR of the cardiovascular system significantly increased when the intravenous drip velocity was beyond 20 drops per minute. The AAR of nervous system and abnormal glycometabolism has no significant correlation with intravenous drip velocity of gatifloxacin. CONCLUSION: Acute adverse reactions of skin, digestive system, and cardiovascular system would decrease with an appropriate velocity of intravenous gatifloxacin (0.2g/100 ml) less than 10 drops per minute.
Source: Saudi Medical Journal
Authors: Jian Xia, Yan Zhao, Hai-Hua Chen, Jian Wang
Institutions: Wuhan University, Zhongnan Hospital of Wuhan University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1500517373