Year: 2012
Type: editorial
Abstract: c-Myc (hereafter referred to as Myc) protein plays a fundamental role in cell cycle regulation, proliferation, differentiation, and apoptosis by modulating the expression of a large number of targets [1]. Expression of Myc is frequently deregulated in human cancers and is often associated with aggressive disease. In non-Hodgkin lymphomas, although Myc has been described as a defining feature and the driving oncogene for Burkitt lymphoma, Myc overexpression has also been recognized in other aggressive B-cell lymphomas and has been linked to adverse prognosis [2]. In addition to Burkitt lymphoma, these aggressive lymphomas include Myc-associated diffuse large B-cell lymphoma (DLBCL), double-hit lymphoma, acute lymphoblastic lymphoma, a blastic variant of mantle cell lymphoma (MCL), transformed
Source: Oncotarget
Authors: Yizhuo Zhang, Xiaohong Zhao, Jianguo Tao
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W1501529729