Relation of allium vegetables intake with head and neck cancers: Evidence from the INHANCE consortium
Year: 2015
Type: article
Abstract: SCOPE: Only a few studies analyzed the role of allium vegetables with reference to head and neck cancers (HNC), with mixed results. We investigated the potential favorable role of garlic and onion within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. METHODS AND RESULTS: We analyzed pooled individual-level data from eight case-control studies, including 4590 cases and 7082 controls. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between garlic and onion intakes and HNC risk. Compared with no or low garlic use, the ORs of HNC were 0.95 (95% CI 0.71-1.27) for intermediate and 0.74 (95% CI 0.55-0.99) for high garlic use (p for trend = 0.02). The ORs of HNC for increasing categories of onion intake were 0.91 (95% CI 0.68-1.21) for >1 to ≤3 portions per week, and 0.83 (95% CI 0.60-1.13) for >3 portions per week (p for trend = 0.02), as compared to <1 portion per week. We found an inverse association between high onion intake and laryngeal cancer risk (OR = 0.69; 95% CI 0.54-0.88), but no significant association for other subsites. CONCLUSION: The results of this pooled-analysis support a possible moderate inverse association between garlic and onion intake and HNC risk.
Authors: Carlotta Galeone, Federica Turati, Zuo‐Feng Zhang, Valentina Guercio, Alessandra Tavani, Diego Serraino, Paul Brennan, Eleonora Fabianova, Jola Lissowska, Dana Mates, Peter Rudnai, Oxana Shangina, Neonila Szeszenia‐Dabrowska, Thomas L. Vaughan, Karl Kelsey, Michael McClean, Fabio Levi, Richard B. Hayes, Mark P. Purdue, Cristina Bosetti, Hermann Brenner, Claudio Pelucchi, Yuan‐Chin Amy Lee, Mia Hashibe, Paolo Boffetta, Carlo La Vecchia
Institutions: Mario Negri Institute for Pharmacological Research, University of California, Los Angeles, University of Milan, Centro di Riferimento Oncologico, Centre international de recherche sur le cancer, Public Health Authority of the Slovak Republic, The Maria Sklodowska-Curie National Research Institute of Oncology, Institutul National de Sanatate Publica, Orszagos Kornyezetegeszsegugyi Intezet, Russian Cancer Research Center NN Blokhin, Nofer Institute of Occupational Medicine, Fred Hutch Cancer Center, Brown University, Boston University, Centre Hospitalier Universitaire Vaudois, Institute of Social and Preventive Medicine, University of Lausanne, NYU Langone Health, New York University, National Institutes of Health, National Cancer Institute, German Cancer Research Center, Deutsches Konsortium für Translationale Krebsforschung, University of Utah, Huntsman Cancer Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Language: English
Topic: Garlic and Onion Studies
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
Awards: Molecular Epidemiology Cancer Training Program, ALCOHOL AND CANCERS OF THE LARYNX AND ESOPHAGUS, Patterns of Somatic Gene Alterations in Oral Cancer, International Head and Neck Cancer Consortium, Pooled Analyses of SNPs and Risk of Head & Neck Cancer, The Boston Collaborative Oral Cancer Study
OpenAlex ID: W1502232377