Work

Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease

Year: 2013

Type: review

Abstract: Mitochondria are no longer considered to be solely the static powerhouses of the cell. While they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple functions, playing key roles in cell survival and death. In this review, we discuss the emerging role of mitochondrial fusion and fission proteins, as novel therapeutic targets for treating a wide range of cardiovascular diseases. Linked Articles This article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2014.171.issue‐8

Source: British Journal of Pharmacology

DOI: 10.1111/bph.12516

Authors: A R Hall, N Burke, R K Dongworth, D J Hausenloy

Institutions: National Institute for Health and Care Research, UCL Biomedical Research Centre, University College London

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,968