Work

RNA Secondary Structure Prediction

Year: 2007

Type: article

Abstract: Details for predicting secondary structure of RNA sequences using free energy minimization are given. Protocols present the use of the RNAstructure computer program (for PCs) and the mfold server (for Unix platforms). The minimum free energy structure and a set of suboptimal structures with similar free energies are predicted. Prediction of high-affinity oligonucleotide binding sites to a structured RNA target is also presented.

Source: Current Protocols in Nucleic Acid Chemistry

DOI: 10.1002/0471142700.nc1102s28

Authors: David H. Mathews, Douglas H. Turner, Michael Zuker

Institutions: University of Rochester, Rensselaer Polytechnic Institute

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: Folding RNA: from Aids to the Human Genome, Supporting RNA structure: Software for RNA Analysis