Work

Delving into somatic variation in sporadic melanoma

Year: 2012

Type: review

Abstract: Melanoma, the most aggressive form of skin cancer, has increased in incidence more rapidly than any other cancer. The completion of the human genome project and advancements in genomics technologies has allowed us to investigate genetic alterations of melanoma at a scale and depth that is unprecedented. Here, we survey the history of the different approaches taken to understand the genomics of melanoma - from early candidate genes, to gene families, to genome-wide studies. The new era of whole-exome and whole-genome sequencing has paved the way for an in-depth understanding of melanoma biology, identification of new therapeutic targets, and development of novel personalized therapies for melanoma.

Source: Pigment Cell & Melanoma Research

DOI: 10.1111/j.1755-148x.2012.00976.x

Authors: Vijay Walia, Euphemia W. Mu, Jimmy C. Lin, Yardena Samuels

Institutions: National Institutes of Health, National Human Genome Research Institute, Johns Hopkins University, Washington University in St. Louis

Language: English

Topic: Melanoma and MAPK Pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,000