Distinct factors bind the AP-1 consensus sites in gibbon ape leukemia virus and simian virus 40 enhancers
Year: 1989
Type: article
Abstract: We have demonstrated that the gibbon ape leukemia virus (GALV) enhancer AP-1 element and the simian virus 40 AP-1 enhancer element bind different factors in HeLa nuclear extracts. A 39-kilodalton HeLa nuclear protein and the c-fos protein bind to the GALV element. Antibodies to c-fos abolish binding to the GALV AP-1 site. In contrast, anti-c-fos immunoglobulin fails to inhibit formation of the simian virus 40-specific complex from extracts of HeLa cells. Thus, AP-1-binding complexes are subject to compositional variation at different binding sites.
Source: Journal of Virology
Authors: J P Quinn, M Takimoto, M Iadarola, N Holbrook, D Levens
Institution: National Cancer Institute
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1503660373