Work

The role of promoter hypermethylation in fibroblast activation and fibrogenesis

Year: 2012

Type: review

Abstract: The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant hypermethylation of a few selected genes plays an important role in facilitating fibrotic fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA methylation and demethylation and their implications for fibroblast activation and tissue fibrosis.Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Source: The Journal of Pathology

DOI: 10.1002/path.4120

Authors: Elisabeth M Zeisberg, Michael Zeisberg

Institutions: Universitätsmedizin Göttingen, German Centre for Cardiovascular Research, University of Göttingen

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Deutsche Forschungsgemeinschaft, Georg-August-Universität Göttingen