Work

Designing T cells for cancer immunotherapy.

Year: 2010

Type: review

Abstract: Adoptive transfer of T cells can enhance immune-mediated elimination of tumor cells and provides a specific, non-toxic cancer therapy. This approach has been effective in treating some hematologic and solid malignancies. In addition, the ability to genetically modify T cells to enhance their activity and persistence as well as overcome tumor immune evasion mechanisms has the potential to increase the success of these therapies in a wide range of tumors. In this review we discuss methods for gene transfer and specific modifications that have been made to T cells.

Source: PubMed

Authors: Leslie E Huye, Gianpietro Dotti

Institution: Baylor College of Medicine

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Awards: ENHANCING T CELL THERAPY OF CANCER, Chimeric T Cell for Therpay of Hodgkin Disease, SPORE in Lymphoma