Work

Influence of Coinfecting Pathogens on HIV Expression: Evidence for a Role of Toll-Like Receptors

Year: 2004

Type: review

Abstract: Immune activation of HIV gene expression as a consequence of the host response to coinfecting pathogens has been implicated as an important factor in AIDS progression. Immune responsiveness to many of the infectious agents associated with HIV has been demonstrated to depend on a family of innate recognition molecules, known as Toll-like receptors (TLR). Therefore, TLR-pathogen interactions could play an indirect role in regulating HIV-associated disease. In this review, we summarize emerging evidence for the influence of TLR recognition on HIV gene activation and AIDS progression.

Source: The Journal of Immunology

DOI: 10.4049/jimmunol.172.12.7229

Authors: André Báfica, Charles A Scanga, Marco Schito, Damien Chaussabel, Alan Sher

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, National Cancer Institute

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1505568786