Work

Using recursive partitioning for exploration and follow‐up of linkage and association analyses

Year: 1999

Type: article

Abstract: We first conducted a genome-wide screen for association with discordant sibships using the multi allelic and diallelic SDT. Markers at D4S1628, D8S1109, D9S66 and D7S1797 showed multi-allelic association. Deleterious diallelic association was found for markers at D1S1613, D1S534, D3S2459, D7S1817, and D9S131. Protective association was found at markers D8S1109, D8S1136, and D9S66. We then incorporated these findings with previous linkage findings in the exploration of oligogenes and epistasis using recursive partitioning. We conclude that recursive partitioning can be a useful adjunct to traditional linkage and association analyses in the exploration of these effects.

Source: Genetic Epidemiology

DOI: 10.1002/gepi.1370170766

Authors: Marsha A. Wilcox, Jordan W. Smoller, Kathryn L. Lunetta, Donna Neuberg

Institutions: Harvard University, Massachusetts General Hospital, Dana-Farber Cancer Institute

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1506043277

FWCI: 0.169

Cites: 6

Cited by: 6

Related to: 10