Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives
Year: 2015
Type: review
Abstract: Retinal degenerative diseases are one of the important refractory ophthalmic diseases, featured with apoptosis of photoreceptor cells. Histone acetylation and deacetylation can regulate chromosome assembly, gene transcription, and posttranslational modification, which are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. The histone deacetylase inhibitors (HDACis) have the ability to cause hyperacetylation of histone and nonhistone proteins, resulting in a variety of effects on cell proliferation, differentiation, anti-inflammation, and anti-apoptosis. Several HDACis have been approved for clinical trials to treat cancer. Studies have shown that HDACis have neuroprotective effects in nervous system damage. In this paper, we will summarize the neuroprotective effects of common HDACis in retinal degenerative diseases and make a prospect to the applications of HDACis in the treatment of retinal degenerative diseases in the future.
Source: Journal of Ophthalmology
DOI: 10.1155/2015/250812
Authors: Hua Zhang, Xufeng Dai, Yan Qi, Ying He, Wei Du, Ji-jing Pang
Institutions: Wenzhou Medical University, University of Florida
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,040
Awards: G3268092671, G3422681555, G4096229155, G4637648831, Vitreal delivery of novel AAV vectors for CNGA3 achromatopsia cone gene therapy, G5557944849, G6259575582, G6637348191, G6728452291, Nanoparticle & AAV Approaches to Rapid Onset, Stable Retinal Gene Therapy, G8708396292, G8886248709, G926211759
OpenAlex ID: W1506578757