Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study
Year: 2015
Type: article
Abstract: OBJECTIVE: To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. METHODS: Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. RESULTS: At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. CONCLUSIONS: Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.
Source: Obesity
DOI: 10.1002/oby.21005
Institutions: Baylor College of Medicine, Houston Methodist Research Institute, Pennington Biomedical Research Center, Wake Forest University Health Sciences, Wake Forest University, St. Luke's-Roosevelt Hospital Center, National Institutes of Health, University of Colorado Denver, University of Washington, VA Puget Sound Health Care System, Harvard University, Massachusetts General Hospital, University of California, San Francisco, University of Tennessee Health Science Center
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: U.S. Department of Veterans Affairs, LifeScan, New York City Department of Health and Mental Hygiene, Massachusetts General Hospital, Massachusetts Institute of Technology, Johns Hopkins University, University of Pittsburgh, Deutsches Krebsforschungszentrum, Herbalife Nutrition, Novo Nordisk, National Institutes of Health, Centers for Disease Control and Prevention, Houston Methodist Research Institute, National Heart, Lung, and Blood Institute, National Institute of Nursing Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Center on Minority Health and Health Disparities, National Center for Research Resources, Office of Research on Women's Health, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: G1017836356, G1069896169, G1135201380, G1203962249, G1235635717, G1315288277, G1428306231, G154671801, G1697512176, G1738385447, G1764474367, G1808778573, G1825392443, G1826705250, G1840982552, G1856819184, G1967037622, G201925267, G2037811546, G2059390010, G2170701390, G2259681657, G2310294257, G2340596590, G2379922715, G2412614087, G2418271037, G2430377532, G2439251763, G2527449299, G2550287350, G2552013629, G2596108490, G2622354101, G2640873770, G2647539983, G2657407243, G2689375212, G2700091228, General Clinical Research Center, G273771255, G2740538849, G2753490813, G2756566231, G286992177, Action for Health in Diabetes Continuation (Look AHEAD-E), G2974145340, G3005483435, G307984963, G3090877473, G3105508146, G3108879679, G3109772807, 05/16 Action for Health in Diabetes Extension Study - Research Project, G3131351768, G3135437339, G316640966, 10/16 Action for Health in Diabetes Extension Study Research Project, G3192100241, G3314471156, G3317573464, G3353711240, G3363638228, G3363681198, G33699332, General Clinical Research Center, 14/16 Action for Health in Diabetes Extension Study Research Project, 02/16 Action for Health in Diabetes Extension Study Research Study, G3423176946, G3461265983, G3466474382, G346895651, General Clinical Research Center, General Clinical Research Center, Institute for Integration of Medicine & Science: A Partnership to Improve Health, G3528332946, G3529252663, G3533025948, GENERAL CLINICAL RESEARCH CENTER, G357792199, G3667465877, G3721678628, G3740642529, University of Pittsburgh Clinical and Translational Science Institute, G384675585, G3853493639, G3886449313, G3953056078, G4186509959, 16/16 Action for Health in Diabetes Extension Study Biostatistics Research Center, G4346870246, G4374570944, G4691857098, G4717514028, G4769937872, G4818134524, G4837651308, G489457639, Atheroregression via Enhanced Reverse Cholesterol Transport, G4929737355, G4936150098, G5025251112, G5032750422, G5135479248, G5171269508, G517149770, G5244746913, G5265194600, 09/16 Action for Health in Diabetes Extension Study Research Project, G5354989911, G5371909057, G538488588, G5524552551, G5559485639, G5575737915, 08/16 Action for Health in Diabetes Extension Study Research Project, G5762116573, G5764153437, 07/16 Action for Health in Diabetes Extension Study Research Project, Colorado Clinical and Translational Sciences Institute, G5867119639, G5894676382, G5939482190, G595004201, G6042631268, G6049454397, G6070369395, G6095923914, G6118008579, G6138801743, Enzymatic Reactions of Plasma Lipoproteins, G618628323, 04/16 Action for Health in Diabetes Extension Study Research Project, G6287513972, G632248976, 03/16 Action for Health in Diabetes Extension Study Research Project, G6463443458, G6474875500, G6478205353, G6557542294, G6692712374, G66933475, 13/16 Action for Health in Diabetes Extension Study Research Project, G6756527295, G676721179, G6805195085, G6814108493, G6860204850, G6873664978, G6961739586, G699274473, 11/16 Action for Health in Diabetes Extension Study Research Project, G7161236425, G7263721568, G730008748, G7348448973, G7369679316, G7370045261, G7377779347, G7423298715, G7479900841, G752626727, 15/16 Action for Health in Diabetes Extension Study Research Project, G7576192191, G7608888979, G7632577458, G7641880336, Harvard Clinical and Translational Science Center (UL1), G7685386930, G7689898056, G7713167540, G7713411732, G77314734, G7792428220, G800164042, G8029094511, Obesity/Nutrition Research Center, G8101982316, G8315761971, G8331318852, G8338615354, 12/16 Action for Health in Diabetes Extension Study Research Project, G8382874639, G8451158733, G8479431427, 06/16 Action for Health in Diabetes Extension Study Research Project, G8552485703, G8568271438, G8601563202, G8650192406, G8709627969, G8856669533, G8890933655, G8921639506, G9000113229, G9000285666, New York Obesity Research Center, Diabetes Research Center, Colorado Nutrition Obesity Research Center, G94176081, G955307958
OpenAlex ID: W1506839237