Work

Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.

Year: 1978

Type: article

Abstract: In HeLa cells which have been exposed to 5 mM sodium butyrate for 21 h, the level of histone acetylation is greatly increased as compared to control cells (Riggs, M.G., Whittaker, R.G., Neumann, J.R., and Ingram, V.R. (1977) Nature 268, 462-464). Our experiments indicate that the increase in the relative amounts of multiacetylated forms of histones H4 and H3 following butyrate treatment is the result of an inhibition of histone deacetylase activity.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(17)34804-4

Authors: L.C. Boffa, G. Vidali, R.S. Mann, V.G. Allfrey

Institution: Rockefeller University

Language: English

Topic: Histone Deacetylase Inhibitors Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430