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Nanoemulsion based Intranasal Delivery of Antimigraine Drugs for Nose to Brain Targeting

Year: 2009

Type: article

Abstract: The objective of this study was to develop intranasal nanoemulsion and gel formulations for rizatriptan benzoate for prolonged action. Nanoemulsion formulations were prepared by constructing pseudo-ternary phase diagrams using lipophilic and hydrophilic surfactants and water. Various mucoadhesive agents were tried out to form thermo-triggered mucoadhesive nanoemulsions. Mucoadhesive gel formulations of rizatriptan were prepared using different ratios of HPMC and Carbopol 980. Comparative evaluation of intranasal nanoemulsions and intranasal mucoadhesive gels indicated that greater brain-targeting could be achieved with nanoemulsions.

Source: PubMed Central

Authors: RS Bhanushali, MM Gatne, R. V. Gaikwad, AN Bajaj, MA Morde

Institutions: Shreemati Nathibai Damodar Thackersey Women's University, Bombay Veterinary College

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1507292278

FWCI: 1.109

Cites:

Cited by: 35

Related to: 10