Work

Glycans Instructing Immunity: The Emerging Role of Altered Glycosylation in Clinical Immunology

Year: 2015

Type: review

Abstract: Protein glycosylation is an important epigenetic modifying process affecting expression, localization, and function of numerous proteins required for normal immune function. Recessive germline mutations in genes responsible for protein glycosylation processes result in congenital disorders of glycosylation and can have profound immunologic consequences. Genetic mutations in immune signaling pathways that affect glycosylation sites have also been shown to cause disease. Sugar supplementation and in vivo alteration of glycans by medication holds therapeutic promise for some of these disorders. Further understanding of how changes in glycosylation alter immunity may provide novel treatment approaches for allergic disease, immune dysregulation, and immunodeficiency in the future.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2015.00054

Authors: Jonathan J. Lyons, Joshua D. Milner, Sergio D. Rosenzweig

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institutes of Health Clinical Center

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801