Year: 2008
Type: article
Abstract: B cells are important in mucosal microbial homeostasis through their well-known role in secretory IgA production and their emerging role in mucosal immunoregulation. Several specialized intraintestinal B cell compartments have been characterized, but the nature of conventional B cells in the lamina propria is poorly understood. In this study, we identify a B cell population predominantly composed of surface IgM(+) IgD(+) cells residing in villi of the small intestine and superficial lamina propria of the large intestine, but distinct from the intraepithelial compartment or organized intestinal lymphoid structures. Small intestinal (villous) B cells are diminished in genotypes that alter the strength of BCR signaling (Bruton tyrosine kinase(xid), Galphai2(-/-)), and in mice lacking cognate BCR specificity. They are not dependent on enteric microbial sensing, because they are abundant in mice that are germfree or genetically deficient in TLR signaling. However, villous B cells are reduced in the absence of invariant NK T cells (Jalpha18(-/-) or CD1d(-/-) mice). These findings define a distinct population of conventional B cells in small intestinal villi, and suggest an immunologic link between CD1-restricted invariant NK T cells and this B cell population.
Source: The Journal of Immunology
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Funders: Crohn's and Colitis Foundation of America, North Carolina State University, Crohn's and Colitis Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, Jonsson Comprehensive Cancer Center, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill
Awards: IBD: Role of Genetic and Immunopathologic Mechanisms, G2239058246, G2356375039, G237424500, Innate Immune Mechanism in Chlamydia Induced Acceleration of Atherosclerosis , G3064394517, G3262768651, National Gnotobiotic Rodent Resource Center, G4057812659, G5408706509, G5665384698, G7286151485, Research Tranining in Cellular and Molecular Biology, IEL B-cells: Phenotype and Developmental Requirements, Regulatory B Cells in Mucosal Homeostasis and IBD, G9000083219, G9000223317, G9000261587, Center for Gastrointestinal Biology and Disease, Cancer Center Support Grant
OpenAlex ID: W1507841898