Isolated aorta model and its contribution to phytopharmacology
Year: 2012
Type: article
Abstract: Since the early 50's until now the isolated thoracic aorta has been a traditional and productive model for pharmacological studies. This experimental model has been closely relatedThe discovery of the role of endothelium in the vasorelaxation induced by acetylcholine (ACh), represented a milestone in biological sciences and also had an important consequence on the isolated aorta preparation. In this work, we describe the isolated aorta technique and the impro...Since endothelium plays a key role on vascular relaxation and its dysfunction is one of first indicators (biomarker) of cardiovascular diseases, the isolated aorta model is a valuable preparation. Considering the great amount of phytochemical present in many natural sources, like vegetables, fruits and medinal plants, we expect this model to continue delivering significant contributions to the knowledge in pharmacology and phytopharmacology.
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1508055735