Work

Building and specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize

Year: 2014

Type: review

Abstract: The past two decades have witnessed incredible progress toward understanding the genetic and cellular mechanisms of organogenesis. Among the organs that have provided key insight into how patterning information is integrated to specify and build functional body parts is the Drosophila salivary gland, a relatively simple epithelial organ specialized for the synthesis and secretion of high levels of protein. Here, we discuss what the past couple of decades of research have revealed about organ specification, development, specialization, and death, and what general principles emerge from these studies.WIREs Dev Biol2014, 3:281–300. doi: 10.1002/wdev.140 This article is categorized under: Gene Expression and Transcriptional Hierarchies > Cellular Differentiation Early Embryonic Development > Development to the Basic Body Plan Invertebrate Organogenesis > Flies

Source: Wiley Interdisciplinary Reviews Developmental Biology

DOI: 10.1002/wdev.140

Authors: SeYeon Chung, Caitlin D. Hanlon, Deborah J. Andrew

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Dental and Craniofacial Research

Awards: G1616064680, Biochemistry, Cellular and Molecular Biology Program, G8609204177, Formation of the Drosophila salivary gland