Year: 2008
Type: dissertation
Abstract: The survival of species is guaranteed by maintenance of genome stability,\nspecifically the protection of DNA integrity. DNA is a chemically reactive molecule,\nwhich is continuously threatened by DNA-damaging agents, both exogenous\n(environmental, including ionizing radiation and mutagenic chemicals) and endogenous\n(byproducts of cellular metabolism, such as oxygen radicals). The continuous onslaught\nby such physical and chemical agents result in about 100,000 modifications per cell per\nday [1], and this calls for the existence of diverse DNA repair systems within the cell. The\nmany different types of lesions that can occur in DNA have necessitated the evolution of\nmultiple pathways to repair specific subsets of lesions. Therefore, an intricate web of\nrepair pathway
Author: Sheba Agarwal
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1509267783