Ventilator-induced mediator release: role of PEEP and surfactant
Year: 2002
Type: dissertation
Abstract: Lung protective ventilation such as the ARDSnet low tidal volumes strategy can reduce\nmortality in ARDS patients. The lmowledge that an essential therapy such as mechanical\nventilation on the intensive care influences patient outcome has given rise to the re-evaluation\nof current ventilation practices.\nThis review addresses the current state of lung protective strategies and their physiological\nrationale. Latest knowledge on the instigation and progression of lung injury by mechanical\nventilation is explored, particularly the interaction between ventilation and the inflammatmy\nresponse occun·ing in an ARDS lung. Furthennore, the role of tidal volume, PEEP,\nrecruitment maneuvers and surfactant on lung injury is discussed. Finally, we discuss results\nfrom clinical studies on mechanical ventilation and elucidate these results with data acquired\nin experimental studies. Guidelines for future strategies and/or investigations are presented.
Author: Jack J. Haitsma
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1509424246