Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence
Year: 2013
Type: article
Abstract: Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non-selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol-preferring P rats, high-alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol-dependent mice at doses which had no effect in non-dependent mice. These findings support the viability of ibudilast as a possible treatment for alcohol dependence.
Source: Addiction Biology
DOI: 10.1111/adb.12106
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1997962874, G2356614167, G2921854259, Rat Animal Models and Gene Testing Core, Rodents with Genetic Differences in Alcohol Preference, Rat Animal Models & Drug and Gene Testing Core (RAM-DGTC), G8686191601, 1/8: INIA Stress and Chronic Alcohol Interactions: Role of Dynorphin/KOR and Oxytocin Systems in Stress-Enhanced Alcohol Drinking, Relapse, and Impaired Behavioral Flexibility, Alcohol Research Center - Treatment and Implications, Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol
OpenAlex ID: W1510797412