Work

Creation of an inositol 1,4,5-trisphosphate-sensitive Ca2+ store in secretory granules of insulin-producing cells.

Year: 1994

Type: article

Abstract: A rapid rise in the cytosolic free Ca2+ concentration due to influx of extracellular Ca2+ or mobilization from intracellular stores is the primary trigger for exocytosis from secretory cells. Our understanding as to the precise role of Ca2+ mobilization has been complicated by the presence of several types of Ca2+ stores in most cells. We now demonstrate that overexpression of the type 3 inositol 1,4,5-trisphosphate (IP3) receptor in insulin-secreting beta TC-3 cells results in the creation of a unique IP3-sensitive Ca2+ pool, restricted to the insulin secretory granules of these cells.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(18)46962-1

Authors: O Blondel, G I Bell, M Moody, R J Miller, S J Gibbons

Institutions: Howard Hughes Medical Institute, University of Chicago

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W1511200882

FWCI: 5.951

Cites: 23

Cited by: 52

Related to: 10