Comparison between the effect of fluconazole and oral protexin combination and fluconazole on the treatment of vulvovaginal candidiasis
Year: 2013
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background: Genital tract infections are one of the main causes of frequent referrals to gynecological clinics. Vulvovaginal candidiasis is the second common infectious vaginitis. On the other hand, probiotics are microorganisms that can have beneficial effects on the host. Noticing the limited number of studies reporting new treatments for this disease, the present study was designed to compare the effects of the of and oral and on the treatment of vulvovaginal candidiasis. Materials and Methods: A double-blind clinical trial was conducted on 90 women who were referred to the 12-e-Bahman Clinic in 2011. The patients were randomly classified into combination of and oral protexin or fluconazole and placebo groups. Data were analyzed by descriptive statistics and inferential statistics (t-test, Chi-square test, Fisher's exact test, and McNemar's test). Results: The combinations, fluconazole-oral and fluconazole-placebo, were equally effective in reduction of complaints and symptoms; however, the effect of fluconazole-oral on dysuria was more (P=0.02). Also, the fluconazole-oral elicited a better therapeutic response (P=0.01). In addition, fluconazole-oral treatment demonstrated a better recovery time (P=0.04). Conclusion: This study demonstrated that complementary treatment with probiotic lactobacillus increased the efficacy of in treatment of vulvovaginal candidiasis. Further research, however, is suggested.
Source: مجله دانشگاه علوم پزشکی اراک
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1511504895